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Sengenics: revolucionando el descubrimiento de biomarcadores de autoanticuerpos
Sengenics es una empresa biotecnológica líder que se especializa en el desarrollo de tecnologías serómicas pioneras en la industria. Las capacidades únicas de la compañía han revolucionado el descubrimiento de biomarcadores de autoanticuerpos clínicamente relevantes, que son esenciales para diagnosticar y tratar diversas enfermedades.
Con sede en Singapur, Sengenics se ha establecido como líder mundial en el campo de la serómica. Las tecnologías de vanguardia de la compañía han sido utilizadas por investigadores y médicos de todo el mundo para identificar biomarcadores novedosos para enfermedades autoinmunes, cáncer, enfermedades infecciosas y otras afecciones.
Lo que diferencia a Sengenics de otras empresas de biotecnología es su enfoque en matrices de proteínas. A diferencia de los métodos tradicionales que se basan en la secuenciación de ADN o ARN para identificar biomarcadores, Sengenics utiliza matrices de proteínas para detectar autoanticuerpos directamente. Este enfoque proporciona varias ventajas sobre los métodos convencionales.
En primer lugar, las matrices de proteínas permiten la detección de alto rendimiento de miles de proteínas simultáneamente. Esto significa que los investigadores pueden identificar rápidamente biomarcadores potenciales sin tener que probar cada uno individualmente. En segundo lugar, las matrices de proteínas son muy sensibles y específicas, lo que significa que pueden detectar incluso niveles bajos de autoanticuerpos con gran precisión.
La tecnología insignia de Sengenics se llama KREX (Killer-REx), que significa "Killer-Exonuclease". KREX es una plataforma patentada que permite la producción de proteínas recombinantes de longitud completa con conformaciones nativas. Esta tecnología permite a los investigadores examinar un gran número de proteínas a la vez manteniendo su estructura y función naturales.
Otra tecnología clave desarrollada por Sengenics se llama ImmuSAFE (Evaluación de firma de inmunoglobulina por emisión de fluorescencia). ImmuSAFE es un método patentado para detectar autoanticuerpos utilizando antígenos marcados con fluorescencia. Esta técnica permite a los investigadores visualizar los patrones de unión entre anticuerpos y antígenos en tiempo real.
Las tecnologías de Sengenics se han utilizado en numerosos estudios de investigación y ensayos clínicos. Por ejemplo, la empresa colaboró con investigadores de la Universidad de Oxford para identificar biomarcadores de autoanticuerpos para la esclerosis múltiple (EM). El estudio, que se publicó en Nature Communications, identificó varios biomarcadores novedosos que podrían usarse para diagnosticar y monitorear la EM.
Sengenics también se ha asociado con varias compañías farmacéuticas para desarrollar nuevos medicamentos basados en sus tecnologías serómicas. En 2019, la compañía anunció una colaboración con Takeda Pharmaceutical Company Limited para descubrir y validar biomarcadores de autoanticuerpos para la enfermedad inflamatoria intestinal (EII).
Además de sus colaboraciones de investigación, Sengenics ofrece una gama de servicios para apoyar el descubrimiento y desarrollo de fármacos. Estos servicios incluyen la expresión y purificación de proteínas, la producción de anticuerpos, el desarrollo de ensayos y el análisis bioinformático.
En general, Sengenics es una empresa biotecnológica pionera que ha transformado el campo de la serómica. Sus tecnologías innovadoras han permitido a los investigadores de todo el mundo acelerar el descubrimiento de biomarcadores de autoanticuerpos clínicamente relevantes para diversas enfermedades. Con su enfoque continuo en la innovación y la colaboración, Sengenics está preparado para hacer contribuciones aún mayores en los próximos años.
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