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Jnana Therapeutics: revolucionando el descubrimiento y desarrollo de fármacos
Jnana Therapeutics es una empresa de biotecnología que se dedica a revolucionar el descubrimiento y desarrollo de fármacos. La compañía combina el descubrimiento profundo de fármacos, la experiencia en desarrollo y los avances tecnológicos para desbloquear objetivos altamente validados pero que anteriormente no podían ser tratados con fármacos. La misión de Jnana es desarrollar terapias innovadoras para pacientes con necesidades médicas insatisfechas.
La empresa fue fundada en 2015 por un equipo de científicos experimentados que reconocieron la necesidad de nuevos enfoques para el descubrimiento de fármacos. Creían que al combinar su experiencia en química, biología y tecnología, podrían crear un nuevo paradigma para descubrir medicamentos que serían más efectivos que los métodos tradicionales.
El enfoque de Jnana se basa en el concepto de "transportadores", que son proteínas que controlan el movimiento de moléculas dentro y fuera de las células. Al dirigirse a estos transportadores, Jnana puede administrar fármacos de forma selectiva a células o tejidos específicos del cuerpo. Este enfoque tiene el potencial de desbloquear objetivos altamente validados pero previamente no farmacables, lo que podría conducir a terapias innovadoras para enfermedades como el cáncer, los trastornos autoinmunes y los trastornos metabólicos.
Una de las tecnologías clave de Jnana es su plataforma patentada para identificar moléculas pequeñas que se dirigen selectivamente a los transportadores. Esta plataforma utiliza métodos computacionales avanzados para predecir cómo interactuarán las moléculas pequeñas con los transportadores a nivel molecular. Mediante la detección simultánea de millones de compuestos contra cientos de objetivos transportadores, Jnana puede identificar rápidamente candidatos prometedores para un mayor desarrollo.
Además de su enfoque basado en transportadores, Jnana también tiene experiencia en otras áreas de descubrimiento y desarrollo de fármacos. La empresa ha desarrollado nuevos ensayos para medir las interacciones proteína-proteína y tiene experiencia en la optimización de la química médica.
La tubería de Jnana incluye varios programas dirigidos a diferentes áreas de enfermedades. Un programa se centra en el desarrollo de inhibidores selectivos de SLC6A20 (un transportador implicado en el metabolismo de los aminoácidos) como tratamiento potencial para la enfermedad renal. Otro programa tiene como objetivo desarrollar inhibidores selectivos contra SLC38A9 (un transportador involucrado en la detección de nutrientes) como una posible opción de tratamiento contra el cáncer.
En general, Jnana Therapeutics representa un nuevo y emocionante enfoque para el descubrimiento y desarrollo de fármacos con un enorme impacto potencial en la salud humana en todo el mundo.
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